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Keyword [Cruzain]
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1. Combining virtual and high-throughput screening in the discovery of new cruzain inhibitors
2. Design of cruzain inhibitors for the treatment of Chagas disease and development and application of methods for the asymmetric synthesis of alpha-branched amines
3. Highly sensitive drug-screening method to find cruzain inhibitors from natural products by liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy
4. Modeling, design, and development of potential inhibitors of gamma-glutamylamine cyclotransferase and inhibitors of cruzain as therapeutic agents for Chagas' disease
5. Design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas
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