Studies On Total Synthesis Of Pauciflorol F And New Approach To Construction Of Indenone

The dissertation aims at the studies on total synthesis of Pauciflorol F and halogenated Helianane, a new approach to construction of Indenone was found which applied in total synthesis of Pauciflorol F. It consists of the following parts:Chapter I: Application of intramolecular Heck reaction in natural products total synthesis (review).Some total syntheses of natural products via intramolecular Heck reaction were reviewed focused on how to construct tertiary carbon and quartus carbon chiral centers.Chapter II: Total synthesis of (± )-Pauciflorol F.Total synthesis of (± )-Pauciflorol F was achieved in 12 steps starting from 3,5-dihydroxybenzoic acid and a new approach to construction of Indenone was found.Chapter III: A new approach to construction of Indenone.A new approach to construction of Indenone was described, including optimization of reaction conditions, exploration of reaction generality and mechanism of reaction.Chapter IV: Asymmetric total synthesis of chloridized Helianane.The total synthesis of chloridized Helianane was investigated starting from 4-methylsalicylic acid. To date, it was in progress.