| The theory and practice of Chinese materia medica are very great andabstruseness, Chinese materia medica modernization is a necessary way forChinese materia medica to the world. The pharmacological reaction of Chinesemateria medica can not only be contributed to its specific chemical composition,but also be closely related to the physics status of the medicine such as the particlesize and etc., and the change of physics status of medicine have a decisive functionfor pharmacological reaction. Nano technology is introduced for the research anddevelopment of modern Chinese materia medica in this paper. It has amplitude'sapplied foreground that application on technology of nanomaterials preparation inthe research of Chinese materia medica modernization.Nano Chinese materia medica is effective composition, the effective part, theoriginal medicine and the medicine's compound of Chinese materia medica, it isprepared by Nano technology and its size is less than 100 nm.Calamine and Sulfur belong to mineral Chinese materia medica, Eveningprimrose oil and on Gamma linolenic acid belong to oil Chinese materia medica.The Nano medicine of Calamine, Sulfur, Evening primrose oil and Gammalinolenic acid are researched, and the application of Nano medicine of Calamine,Sulfur, Evening primrose oil and Gamma linolenic acid are studied in this paper.The components of Chinese materia medica calamine were determined withthermogravimetric analysis method and otherwise. Nanosized zinc carbonate alkaliand nanosized zinc oxide were synthesized, and nanosized calamine was prepared.The particle size and morphology of calamine, zinc carbonate alkali and zinc oxidewere determined by laser size analysis device and transmission electron microscope (TEM). The antibacterial activity of calamine and its components weredetermined by using beaker disc method. The result shows that the antibacterialactivity of calamine was decided by the content and particle size of zinc oxide, andthe antibacterial activity of nanosized calamine were better than that of calamine.Nanosized calamine possesses the characters of calamine and nanosized Chinesemateria medica, and it has the double activities of calamine and nanoparticles.Zinc carbonate alkali and nanosized zinc carbonate alkali have not antibacterialactivity for the four bacteria in this paper.A novel and simple liquid-synthesis reaction in the presence of a surfactant,polyethylene glycol-400 (PEG-400), has been developed to synthesize sulfurnanoparticles with different diameters by using sublimed sulfur powders,ammonium sulfide and acetic acid under room-temperature condition. Themorphology of sulfur nanoparticles is characterized by TEM, X-ray diractometer(XRD), infrared ray spectra device(IR), and thermogravimetry analysisinstrumen(tTG). The TEM image shows that the size of sulfur nanoparticles is 40–60 nm. This work has demonstrated a novel route to produce nanosized sulfurparticles via the liquid-synthesis technique, and a method that could be applied toextensive and low-cost production.Nanosized monoclinic sulfur particles have been successfully prepared viathe chemical reaction between sodium polysulfide and hydrochloric acid in areverse microemulsions system, with theolin, butanol, and a mixture of Span80and Tween80 (weight ratio 8: 1) as the oil phase, cosurfactant and surfactant,respectively. Transparent microemulsions were obtained by mixing the oil phase,surfactant, co-surfactant, and the aqueous phase in appropriate proportion using anemulsification machine at the room temperature. The resulting sulfur nanoparticleswere characterized by dynamic light scattering, XRD, IR and TEM.The supramolecule inclusion compounds of β-cyclodextrin with Eveningprimrose oil or Gamma linolenic acid were study by using the supramoleculetechnology, the properties of compounds were investigated by elementary analysis,XRD and IR etc., the tiny powder of Evening primrose oil or Gamma linolenicacid were prepared. Nanocapsule of Gamma linolenic acid were preparedsuccessfully by using microcapsules technology.The microemulsions of Gamma-linolenic acid methyl ester, the purpose ofthis study was to investigate the possibility for parenteral delivery of Gammalinolenic acid methyl ester without chemical modification using a microemulsiontechnology. Microemulsions composed of Gamma linolenic acid methyl ester andPolysorbats were prepared using PEG-400 as a cosurfactant. The effect offormulation variables on the particle size of the microemulsion was investigated.instrumen(tTG). The TEM image shows that the size of sulfur nanoparticles is 40–60 nm. This work has demonstrated a novel route to produce nanosized sulfurparticles via the liquid-synthesis technique, and a method that could be applied toextensive and low-cost production.Nanosized monoclinic sulfur particles have been successfully prepared viathe chemical reaction between sodium polysulfide and hydrochloric acid in areverse microemulsions system, with theolin, butanol, and a mixture of Span80and Tween80 (weight ratio 8: 1) as the oil phase, cosurfactant and surfactant,respectively. Transparent microemulsions were obtained by mixing the oil phase,surfactant, co-surfactant, and the aqueous phase in appropriate proportion using anemulsification machine at the room temperature. The resulting sulfur nanoparticleswere characterized by dynamic light scattering, XRD, IR and TEM.The supramolecule inclusion compounds of β-cyclodextrin with Eveningprimrose oil or Gamma linolenic acid were study by using the supramoleculetechnology, the properties of compounds were investigated by elementary analysis,XRD and IR etc., the tiny powder of Evening primrose oil or Gamma linolenicacid were prepared. Nanocapsule of Gamma linolenic acid were preparedsuccessfully by using microcapsules technology.The microemulsions of Gamma-linolenic acid methyl ester, the purpose ofthis study was to investigate the possibility for parenteral delivery of Gammalinolenic acid methyl ester without chemical modification using a microemulsiontechnology. Microemulsions composed of Gamma linolenic acid methyl ester andPolysorbats were prepared using PEG-400 as a cosurfactant. The effect offormulation variables on the particle size of the microemulsion was investigated. |
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