| Because of the large flexibility and good coordination capability of Schiff base ligands, studies on Schiff base metal complexes are paid much attention, with lots of novel properties showing in biochemistry, catalysis, electrochemistry, etc. But a few of keto Schiff base complexes were reported. Transition metal Schiff base complexes possess special structures, properties and widely uses, such as oxidation-reduction, catalysis and chemical simulation for biological systems. Rare earth metal Schiff base complexes also possess biological, catalyst properties and can be used as photomagnetic materials. Because some Schiff bases have special antitumor activities, they attract more and more attention in medicinal field. Whilst most of the reports dealing with metal complexes exhibiting antitumor properties are confined to cisplatin analogues, there is a growing number of non-platinum metal compounds which also exhibit remarkable anticancer activities. Therefore, we firstly synthesized and characterized eight keto Schiff base ligands and their transition and rare earth metal complexes. The antitumor activities and fluorescence properties of the part of the complexes were studied.1. A brief view of the research progress for Schiff base compounds was given.2. Eight ligands and their transition, rare earth metal complexes were synthesized and characterized. The compositions and structures of the complexes were determined by elemental analysis, molar conductance, IR, UV-Vis, 1H NMR, etc. The crystal structures of the following eighteen complexes were analyzed: L1·Cd(pic)2, L2·Fe(ClO4)3, L3·Cu(OAc)2, L3·ZnCl2, L3·CoCl2, L3·Mn(pic)2, L3·Cd(pic)2, L3·Ce(pic)3, L3·Nd(pic)3, L3·Eu(pic)3, L3·Y(pic)3, L3·La(NO3)3, L3·Ce(NO3)3, L3·Nd(NO3)3, L5·Zn(OAc)2,L8·Cu(OAc)2, L8·Ni(OAc)2, L8·Mn(OAc)2.3. Antitumor activities and fluorescence properties of some the ligand and complexes were determined. Using the method of MTT, we determined inhibition function of ligand L1, L3, L5, L8 and their corresponding complexes in human leukemia cells line (HL-60), lung cancer cells line(SPCA-l), tongue cancer cells line(Tb), stomach cancer cells line (MGC) and leukaemia cells line (K562). By killness of these several cells brought up outside, we compared antitumor activities of the ligands and their complexes. The results told me they all had killness in some degree to these cells, especially Cu(II) complexes which show favorable antitumor activities, their inhibition function were better than other complexes and homologous compounds reported before. We determined fluorescence spectrum of Schiff base and corresponding complexes, fluorescence intensity of the ligands were smaller than that of the complexes. And we compared the fluorescence intensity of several complexes in different solvents or with different acid radicals.
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