| Ventricular remodelling(VR) following myocardial infarction (MI) is defined as changes in shape and size of the ventricle following acute myocardial infarction. Statistics suggested that its incidence rate was 30%-50%. VR is always a progressive process and it is one of the most important causes of death of later cardiac disease, so most scholars think that the new treat on MI should be antiremodelling of Ventricular. Reseaches showed that autocrine and paracrine of Rennin-angiotensin system(RAS) probably has an important reverse regulation on the left ventricular remodelling and Angiotension II (Ang II), may be the core of a series of biochemical reactions, is working by ATi receptor. There is no study on treatment on left ventricular remodelling following MI with traditional Chinese medicine (TCM). It has a great significance that we take systematic researches on the mechanisms of left ventricular remodelling following MI in order to improve the theory of traditional Chinese medicine and exploit new traditional Chinese medicine.VR following MI belongs to xiongbi, xintong and zhenxintong in TCM. The main mechanisms are deficiency of qi and yin, stagnancy of phlegm and qi. Kaixin capsule II is a recipe made by my teacher on his experience. It consists of the main components of shengmaisan, shixiaosan zndyuejuwan. It had been proved to have effective treatment on VR following MI. The effect of Kaixin capsule and Ang II were researched on the disease model of left ventricular remodelling which was made by ligating rat's left coronary artery.50 SD rats, half male and female, were randomly divided into 5 groups (n=10). From the third day on after the model was finished, high dose Kaixin capsule group and low dose Kaixin capsule group was respectively received Kaixin capsule lOg-k^.d"1 and 5 g-k^.d"1 . Captopri group was received Captopri in water. MI group and pseudooperation group were feed normally. 8 weeks later, we measured cardiac function, sucked out the blood in hearts then weight the hearts and left ventriculars. Some of the hearts no MI were sect into fragments and stored in liquid nitrogen, the others were sliced four times every 1.5-2mm from basis cordis to cardiac apex, which paralleling atrioventricular sulcus after being fixed up with formaldehyde and embeded. The blood was stored at -20 *C after centrifugation.1. The effect of Kaixin capsule on the shape and function of left ventricle following MI in rats.Remodelling of ventricular and myocardial cell following MI was one of important factors in deterioration of cardiac function. We investigated cardiac construction and the effect of Karxin capsule on it. The sizes of MI in four groups were respectively 36.52?.24, 38.14+4.07, 37.49?.19, 37.16?3.57,which was calculated by the average circulation method, there is no significant difference (P>0.05) among them. The cardiac index, mean of area in left cardiac cavity, area and depth of interventricular septum were all significance increased in MI group compared with pseudooperation group(P <0.01), but these values of high dose and low dose Karxin capsule groups were decreased compared with these of MI group. It was proved that Kaixin capsule could restrain the dilation and hypertrophy of left ventricular and had beneficial effect on ventricular remodelling following MI, if being used for a long time.2. The effect of Kaixin capsule on collagen reconstruction in non-infarcted zone of left ventricular.Collagen's over-sedimentation can make myocardial harden which affects cardiac function. Damage of collagen relates to not only its amount, but also its type and distribution. We observed the effect ofKaixin capsule on the total amount, types and distribution of myocardial collagen in non-infarcted segments of left ventricle in rats by combining the method of hydroxyproline and Sirius Red F 3B 200 with image analysis. The results showed that both the myocardial collagen's total amount(33.33?.38) and the rate of collagen I/collagenIII(9.58?.86) increased sign...
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