Clinical And Experimental Study Of Huanglian Qingjiang Mixture Treating Hypertension

Based on the studies of the hypertension's clinical features and the relationships between this disease and the environmental factors, the emotional activities, the life styles, the diet habits, the physique, this thesis explores the new etiology pathogenesis of the hypertension in order to find a new effective prescription to treat it. The research puts forward the pathogenetic hypothesis, which is the hypertension ascribes in the intense fire in the heart and the liver, excess of evil heat in the interior. The principle of therapy is purging the liver and tranquilizing the heart, clearing the heat and detoxify. According to this, herbs are choosed precisely and the prescription is composed rationally, then the HLQJ (Huanglian Qingjiang) mixture is prepared by using modern technology. 35 patients with hypertension I or II were treated by taking HLQJ mixture, with another 30 hypertension patients taking Niuhuang Jiangya pills as the control group. The result of animal experiment is also a proof of its effect.As for the HLQJ mixture group, the prominent effective rate in blood pressure reducing is 62.86% and the total effective rate is 85.71%. The effective rate of improving symptoms is 65.71% and the total effective rate is 91.42%. As for the control group: the prominent effective rate in blood pressure reducing is 23.33% and the total effective rate is 70%. The effective rate of improving symptoms is 20% and the total effective rate is 73.33%. There is significant difference between the two groups (P<0.05). In addition, the effect of the HLQJ mixture on the patients' 24-hour dynamic blood pressure was observed. Results show that the HLQJ mixture can improve theaveraged change of the 24-hour dynamic blood pressure of the patients. Furthermore, the systolic and diastolic pressure in daytime and night were both lowered. And the ratio between the highest and the lowest can be improved. There is significant difference before and after the therapy (P<0.05). The HLQJ mixture can also lower the lipoprotein in the blood, improve the hemorheology, the myocardial ischemia and the cardiac arrhythmia, enhance the diastolic function of the heart and improve the arteriosclerosis in eyegrounds. And it has no toxicity and side effects.The animal experiments show that the HLQJ mixture can obviously lower the systolic pressure of SHR, appearing evident time-effect and dosage-effect. It can lower the content of Angll, ET-1 and NE in SHR's plasma, decrease the ratios between the heart and the body, the kidney and the body, improve the change in the structure of the aorta and kidney artery, and reduce the ratios between the thickness of the artery mesosphere and semi diameter of the vessel, the surface area of mesosphere and the surface area of the vessel. In some degree, it has the ability to deteriorate the damage in the target organ of SHR.Intense fire in the heart and the liver and excess of evil heat in the interior are the important mechanism of the hypertension. So purging the liver and tranquilizing the heart, reducing the fire and detoxifying are the important therapies to the hypertension. The HLQJ mixture has not only prominent clinical curative effect, but also substantial pharmacologic and potent fundament. It is an effective compound prescription of treating hypertension. The mechanism of the HLQJ mixture treating hypertension maybe has relationship with RAS, ET and NE. This paper puts forward the pathogenetic theory that the hypertension ascribes to evil heat production in the interior. It enriches the therapeutics of TCM treating hypertension and provides a new way for the therapy to the hypertension with TCM.