Clinical And Experimental Studies Of Drink Liquor And Thrombus Formation

The purpose of this task is to determine the dangerous degree that drinking spirit has on thrombus diseases(myocardial infarction,cerebral embolism) .The task is held by clinical study and experimental study.The clinical study chooses 1013 patients who has been diagnosed as myocardial infarction or cerebral embolism as study targets.The task describably studies their disease datum by review study.It devides patients into groups according to dose of spirit and observes the effects of spirit dose have on blood pilids levels,blood sugar,blood pressure ect. of male heart or brain thrombus diseases patients.The result indicates: 1 the persent of drinkers among all patients is 55.70% , among drinkers the persent of male is 72.88% . These persents are significantly higher than drinking spirit rate of non-thrombus diseases.Drinking spirit is the one of important factors in thrombus diseases of heart or brain. It has been found the mechanism that spirit affects heart or brain thrombus diseases is turned into reality by affecting TC and DBP by logistic multivariate regression analysis.2 Advanced age , obesity , high-TC blood syndrome , high blood sugar , high blood pressure are all dangerous factors of heart or brain thrombus diseases. 3 Among smokers low-dose spirit can raise blood pressure.The effect of raising blood pressure is large if spirit and smoking are combined. 4 No matter whether smoke the wet and heat syndrome marks of high dose spirit group and moderate dose spirit group are higher than those of low dose spirit group and non-spirit group. That is to say, high and moderate spirit group can cause wet and heat syndrome.It has not been found low dose spirit group can lower the mark of extravasating blood syndrome.The experiment observes effects of spirit having on length of thrombus in rat's tails and effects of spirit on coagulation and fibrinolysis.Method:the rats were randomly allocated into six groups,ten rats each group:the model control group;the normal controlgroup; the aspirin group ; the low dose spirit group ; the moderate dose spirit group ; the high dose spirit group. After the rats were fed for 4 monthes , besides the normal control group , other 5 groups were used to establish tail-thrombus models with carrageenan . Then observe the length of dark tails at different time . After the models were established for 72 hours , the blood in vein was drew to observe PT, FB, TT, PAI and t-PA. Conclusion : The experiment proved : moderate and high dose spirit can enhance the formation of thrombus in rats caused by carrageenan. Low dose spirit and oral aspirin have no obvious effect on the formation of thrombus in rat's tails.