Clinical Epidemiological Study On The Law Of The Differentiation Of Syndromes Of Coronary Heart Disease

Objective: To explore the clinical differentiation of Syndromes character and law of coronary heart disease(CHD)Method:1. Investigation of literature: The literature of today and old was studied systematically, to know the character of distribution and research progression of CHD and analyzed the pertinent literature and paper generally by Meta-analysis to study the correlation of blood lipids changes and differentiation of Syndromes law of CHD.2, Clinica epidemiological study: By the whole random sampling, epidemiological survey of differentiation of Syndromes law of CHD on residents above 45 in Changsha city was made. Simultaneously, we detect the correlation markers of blood lipids , the function of coagulation and fibrinolytic system * the vessel endothelial cell function and ECG on patiens of CHD and healthy person to explore the correlation of these correlation markerss and the differentiation of Syndromes of CHD.Results:1. Investigation of literature:(1) The literature of today and'old was studied systematically, we found it was short of unification specification and cognition although there was much TCM differentiation of Syndromes of CHD,thought existing various kinds of method and thinking of differentiation of Syndromes of CHD is significant to clinical and research of CHD,but it was based on clinical reports and individual experience in defect of observation of clinical Syndromes. Clinical and research thought much of objectivity research ignoring research of Syndromes component itself.(2) With quantu analysis of stochastic effect of Meta-analysis, wefound content of blood lipids of CHD patien of heart blood stasis Syndrome and coagulation of phlegm Syndrome all had change. Change of TC, TG, LDL-C could be objective marker of differentiation of Syndromes of CHD2. Epidemiological study:(1) According to variance cluster, the symptom of CHD patient could be divided into seven nest of Syndromes(2) On the basis of results of logistic regression analysis and principal component analysis, we gaineded principal symptom statistically significant to Syndromes diagnosis of TCM.(3) By logistic regression analysis, we found correlative risk factor of CHD of heart blood stasis syndrome was age, body mass index, triglyceride, hight density lipoprotein-cholesterol, antithrombin III.( 4 )Detect results showed: the correlation markers of blood lipids.the function of coagulation and fibrinolytic system all have relations with Syndromes of TCM of CHD.conclusions:1. According to results of cluste analysis and principal component analysis, familiar syndromes of CHD could be sum up to seven kinds:The Syndroms of Obstruction of the Heart Collaterals and Vessels resulting in stagnation of heart-blood, cold, coagulation of phlegm, qistagnancy, Syndromes of Deficiency of Heart-Qi , Heart-Yin, Heart-Yang.2. On the basis of results of investigation achievement before, investigation of literature and our epidemiological study, seven familiar kinds of differentiation of Syndromes standard of CHD were set up.3. Cluste analysis , logistic regression and analysis principalcomponent analysis is helpful to classification of elementary Syndromes of TCM.4. At present,it is significant practically to carry out epidemiological study of Syndromes of TCM of CHD.