Toxic Mechanism And Treatment Of Hydrogen Cyanide In Fire Smoke

This paper was aimed to study the toxic mechanism and anti-cyanide measures to hydrogen cyanide (HCN) in fire smoke. It was found in the laboratories that there were various kinds of toxic gases in the smoke released from the combustion of nonmetal materials of cabin, including carbon monoxide (CO) and hypertoxic HCN which may cause acute toxic effects to persons who inhaled them. And there was synergistic toxic effect between HCN and CO in fire smoke. By the study of concomitant intoxication of HCN and CO, it was showed that determination of blood concentration of cyanide and activity of cytochrome oxidase was only to be the exposed sign, and activity changes of enzyme were mainly affected by HCN and CO has insignificant effects on it. In the case of intoxication of sublethal doses of cyanide, anti-cyanide effect of hydroxocobalamine was close to that of methemoglobin formers, and it can be used to antagonize cyanide in the patients who were suspected of HCN intoxication after inhalation of fire smoke, which can avoid the conflict of heavier anoxia produced by forming methemoglobin in conventional anti-cyanide therapy.