Susceptibility Genes For Parkinson Disease

Objective To investigate the association between eleven polymorphisms ofeight candidate genes, dopamine beta hydroxylase(DBH), catechol-O-methyltransferase(COMT), monoamine oxydase A and B (MAOA, MAOB), dopamine transpoter 1(DAT1), α-synuclein, Parkin, γ-synuclein with the susceptibility of Parkinson disease(PD). Methods Association study was performed in 154 PD patients and 210healthy subjects. Polymorphisms of each gene were genotyped with polymerase chainreaction (PCR). Results 1. Polymorphisms of DBH, MAOB and α-synuclein geneswere associated with PD risk (For DBH A2/A2 genotype, OR=2.094; for MAOB(GT)n 168bp, 170bp, 184bp, 186bp alleles total, OR=3.976; for α-synuclein (GT)n265bp allele, OR=6.183), but not COMT, MAOA, DAT1, Parkin, γ-synuclein genespolymorphisms, and α-synuclein mutations. 2. The COMT G/G genotype increasedthe DBH A1/A2-PD risk(OR=5.633)and the COMT G/A genotype combined withMAOA T genotype can also confer an increased risk for PD (OR=2.727). Individualswith DAT1-440/480-MAOA-T genotype had high risk for PD. 3. DBH A2 allele,MAOA T and parkin A/A genotypes were more related to PD in male. MAOA T andCOMT A/A genotypes might be risk factors of tremor onset PD, and γ-synuclein geneC/G genotype, rigidity onset PD. DBH A2 allele was risk factor of left side of bodyonset PD, and COMT A/A genotype, right side onset. DBH, MAOB , and COMTgenes might modify the onset age of PD. Conclusion DBH, MAOB, α-synucleingenes were associatied with PD risk. And polymorphisms chosen in MAOA, COMT,DAT1, Parkin, and γ-synuclein genes were mini-risk factors of PD.