| Dementia is a disease of acquired intelligence injury syndrome, caused by brain dysfunction. The incidence rate of Senile Dementia has been inclining to climb up, along with aging population. This has been an outstanding problem of society and medical science. Dementia therapy is a key point of improving the life quality of the aged. Dementia is a parenchymal disease, mostly irreversible. No satisfying therapy has been developed and those aimed to entity is still under research. Some promising progresses have been made in tentative drug treatment to several kinds of causations, some of whose symptoms are ameliorated. At the same time, traditional Chinese medicine (TCM) possesses great potential to fight against Dementia. Hopes lay in summarizing and uncovering effective components, and the creation of unitive pharmacody model, including observing guidelines and quantitative evaluation of effects. Therefore, applying the combination of TCM and west medicine to Dementia therapy is an urgent topic and we discussed its clinical effects. In comparison to west medicine, TCM, the gem of our country, has accumulated rich theories and practical experiences in postponing senility, and prevention and cure of the related diseases. Thus, TCM has great potential and bright prospect to be developed. Investigations revealed that estrin protects female cognitive function. We designed contrast researches to observe how estrin affects female patients with Alzheimer's Disease (AD), suggested the possibility of cholinesterase inhibitor copulated with estrin for cure, and reached the objective of ameliorating cognitive function of Senile Dementia sufferers. This article found promising effects of the combination of TCM and west medicine to Dementia therapy by observing research of treatment and rehabilitation. In short, finding operative ways of prevention and cure, ameliorating and improving the patients' life quality and ability to adapting the society, and lessening dysresults of Dementia, do possess great significance.First of all, we researched the effects of using LuoTai(络泰)to treat Senile Dementia which means Vascular Dementia and Alzheimer's Disease here. Vascular Dementia and Senile Dementia (AD) probably share the same symptom of brain blood flow decrease. The effective component of LuoTai is ginsenoside R1, which is sterile dongganfenji, characterized with high stability. Experiments showed that ginsenoside can obviously protect rat brain from ischemia reperfusion injury, by dilating blood vessel, enhancing blood flow, ameliorating ultrastructure injury of brain edema, and decreasing death rate. This protective function is closely related to the accumulation of calcium. Clinical application proved its ability of dilating blood vessels, enhancing blood flow, ameliorating microcirculation, evidently preventing late neur injury of hippocamp's CAI domain(related to study and memory) after brain ischemia, and resisting inflammation thus resisting AD and VD.Clinical practic also certified that ginseng is an effective TCM to prevent and cure AD Its active component ginsenoside has similar effects as estrin to ameliorate memory and protect nerve. Estrin takes part in central nervous system control, and intrinsic estrin is a protective factor of AD, and its replacement therapy is beneficial to the prevention and cure of AD. So, as a kind of TCM that having the same function of estrin, ginsenoside can be applied as a replacement of estrin and is important to prevent and cure of AD. During the course of animal aging, disturbance of calcium metabolism causes overload of free calcium in neuron, reduces neuron's compliance, and then obstructs memory. Li Linxian 's research made clear that one of the mechanisms of improving intelligence is in virtue of the effective component Rb1's ability to reduce [Ca2+]i and calcium protein activity, and cerebral infarction domain decrease.Next, we researched the effects of using TCM to treat Vascular Dementia. The researched prescription is: mongolian milkvetch root, safflower, barb... |
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