| PART â… Retrospective Study on Uremic Cardiomyopathy 1.Objective:To summarize the clinic feature in differential syndrome of TCM of uremic cardiomyopathy patients. 2.Method:Using a retrospective study design to investigate the chronic renal failure (CRF) patients with uremic cardiomyopathy.53 cases rage 24-87 years old with uremic cardiomyopathy of at least one half year's duration were enrolled,included 37 cases of chronic glomerulonephritis,7 cases of nephrotic syndrome,4 cases of obstructive nephropathy, 3 cases of lupus nephritis,and 2 cases of polycystic kidney disease. 3. Result:3.1 Of the uremic cardiomyopathy,spleen and kidney Qi deficiency (34 cases,64.2%),spleen and kidney Yang dificiency (7 cases,13.2%)are the main.3.2 In the course of uremic cardiomyopathy,usually more than 2 cases of excess syndromes are mingled. The frequency of different types of excess syndrome from high to low is linger and stagnation of damp turbility and static blood(36 cases,66.7%),water damp(7 cases, 13.2%).3.3 Through the analysis of UCG,two stages of uremic cardiomyopathy have obvious difference.As a result of cardiac hypertrophy,ventricular delated, the function of heart decreased.4.Conclusions:4.1 Uremic cardiomyopathy subjects manifested as deficiency syndrome mingled withexcess syndrom. In the deficiency syndromes,spleen and kidney Qi deficiency, spleen andkidney Yang dificiency are the main.In the excess syndromes, linger and stagnation ofdamp turbility and static blood are the main.4.2 In the early stage of uremic cardiomyopathy,myeocardial reconstruction has play a rule.The myocardial damage is strongly related with CRF.PATE â…¡ Experimental Sudy on Uremic Cardiomyopathy Rats Treated withDunaiqing Granules1.Objective:To clarify the efficiency and passible mechanisms of Dunaiqing Granules in the remic cardiomyopathy rats. 2.Methods:Fifty male SD rats were made uremic cardiomyopathy.45 successful model rats with CRF were divided into five groups randomly.Model Group(administered with NS 2ml/d),High Dose Group(administerde with Dunaiqing 4.5g/kg.d),Low Dose Group (administered with Dunaiqing 2.25g/kg.d),Captopril Group(administered with 6.25mg/ kg.d).9 age-matched male SD rats were sreved as controls(administered with NS 2ml/d) 8 years later, contents of serum creatinine(Scr),BUN were determined.The myocardial ultrastructure of lefe ventricular (LV) were observed through transmission electric microscope,collagen volume fraction were calculated with automatic imaging analyzing system after VG staining.The apoptosis of myocardial cells was mensured by TUNEL methods. 3.Results:3.1 The condition of Model Group deteriorate.The level of BUN,Scr was significantly increased than Control Group.The rats' condition of Dunaiqing's two dosage groups were inproved obviously than controls,especially the hign dose group.The conditions of aptopril Group is lightly improved.3.2 Under the microscope,the model group's myocardial cells nucleus contract,and the original fiber of muscle arranges mess,etc.Both Dunaiqing and Captopril groups have obviously improved the pathological changes showed in ultrastructure:the myocardial cell nucleus slightly tidy,the muscle syrup inside track is more.muscle cell nucleus near to normal.3.3 The level of HWI and LVMI, and the lecel of CVF and PVCA in Captopril Group and Dunaiqing Groups were significantly lower than models.3.4 Apoptosis was found in Control Group by chance.In the Model Group apoptosis of myocardial cells were detected.The apoptosis index(AI) of Captopril Group and both of Dunaiqing Groups have a obvious decline.4.conclusion:4.1 The uremic cardiomyopathy rats appeared pathological changes in ultrastructure.
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