Study On Synthesis And Adsorption Properties Of Cellulose Derivatives

Chronic renal failture(CRF) is a serious disease with clinical poisonous symptom,The pathogeny is that many toxins such as urea, creatinine and uric acid are saved inhuman body. The development of novel oral adsorbents with high adsorption capacity,broad spectrum and less side effect is significant for delaying disease progress. In thispaper a series of cellulose derivatives were developed with cellulose as carrier toremove three toxins. These derivatives are 2,3-dialdehyde cellulose(DAC), coated2,3-dialdehyde cellulose(CDAC), epoxycellulose(EC), cross-linked cellulose(CLC),nitrocellulose(NC) and cyclodextrin grafted cellulose (CDGC).The orthogonal experiments study on oxidizing α-cellulose to DAC with sodiumperiodate (NaIO4) was carried out. The principal factors influencing the aldehydegroup content of DAC were found out and the better oxidation conditions were as thefollowing: The pH was 2. The reaction temperature was 45℃. The weight ratio ofcellulose to NaIO4 was 1:2. The reaction time was 4h. The high aldehyde groupcontent was obtained under above condition. The CDAC was prepared by coatingwith gelatin and chitosan. The kinetic curves of adsorption, the first-order and thesecond-order kinetic models were used to describe the adsorption ability of DAC andCDAC for urea under various conditions. The adsorption for urea has two steps. Oneis first-order kinetic model before 8h, Another is second-order kinetic model after 8h.The most high adsorption capability is 59.22 mg/g.The synthesis of epoxycellulose and cross-linked cellulose from epoxychloropropane (ECH) and ethanodiol diglycidyl ether ( EGDE ) in the presence ofalkali medium were described. The principal factors affecting the epoxy group contentwere found out and the best conditions were as the following: the weight ratio ofcellulose, epoxy chloropropane and 30%NaOH(g/mL/mL) was1:6:8, The reactiontemperature was 40℃. The reaction time was 2.5h. The adsorption capacity forcreatinine was observed with epoxycellulose and cross-linked cellulose. Theadsorption capabilities are 1.1mg/g and 5.12mg/g, respectively.NC, β-cyclodextrin(β-CD) grafted cellulose, and methyl-β-cyclodextrin graftedcellulose were synthesized from EC carrier by grafting with 3,5-dinitrobenzoicchloride(DNBC-Cl), β-CD and methyl-β-CD. Nitrobenzene ring and creatinineformed complex. The CDs had inclusion for uric acid. Thus creatinine and uric acidwere adsorpted.The cellulose derivatives were put into fibroblast for the cytotoxicity experimentto imitate the human body environment. The MTT method assay showed that abovederivatives had hormesis.The rats were treated with CDAC by input-stomach after the chronic renal failurerat model was established. The creatinine and uric acid were obviously reduced in thetreatment rats model with CDAC. The CDAC had good curing effect.