Antitumor Effects Of Murine Interleukin-23 Mediated By Retrovirus And Related Mechanism

Tumor is one of the serious diseases threatening human health. Development of tumors is related to a defect of a host immunosurveillance system and an escape mechanism of tumors from host immune responses. At present, operation, chemothreapy and radiotherapy are the main meathods to treat tumors with some limitations. Immunotherapy of tumors which can not only enhance the immune function of host, kill tumor cells in specific way, but also has less side-effects on normal tissues and more and more people have pay attention to immunotherapy. Cytokines possess pleiotropic functions and mediate systemic and local biological actions, which relate to cell growth and differentiation, immune function and inflammation. There are some effects by administration of some cytokines directly in treatment of tumors. Because of the short half-life, large and lasting usage and strong side-effects of cytokines, they are limited in clinical application. Therefore, it is necessary to looking for more effective cytokines and new administration approachs. Cytokine gene therapy is one of the therapeutic strategies of tumors, in which cytokine genes are transduced into some vectors such as tumor cells, dendritic cells and fibroblasts. The vectors carried cytokine genes in host can last production of cytokines that can induce immune responses to tumors and overcome the drawbacks of short half-life, large and lasting usage and strong side effects of cytokines by direct administration. Besides, tumor cells and dendritic cells loaded tumor antigens as cytokine gene therapeutic vectors can provide the antigens to induce specific antitumor responses.Interleukin-23 (IL-23) is a cytokine reported by Oppmann et al in 2000, which can enhance proliferation of memory T cells and production of interferon-γ (IFN-γ) and IL-12 from activated T cells and dendritic cells. IL-23 has also been considered essential to development and control of autoimmune...