The Finding And Treatment Of Second-secondary Injury Of Spinal Cord Injury In Rats

In most countries, the annual incidence rate of spinal spinal cord injury (SCI) is 20-40 person in ever million. Although the protective measures have been switched on, there is no indication that the rate will be diminished. The primary cause of SCI is road accident(45.4%), and other causes include falling from high locality and athletic injury whereas the SCI caused by colliery accident is striking in China. SCI often leads to lifelong disability of the patient, resulting in enormous suffering and burden of the family and society. During the period of postinjury of SCI, there is a secondary lesion caused by the primary injury, which leads to a even greater injury several times more than the original injury. Therefore, how to relieve the secondary injury is the hot topic studied internationally for the past many years. However, up to now, there isn't acknowledged method to relieve the secondary injury except for the large doses of Methylprednisolone, that has some effect.In order to achieve the rational therapy for human SCI, there must be a standardized and duplicable animal model. Now, the rats' impact injury model created by the New York University in America is the most frequently used animal model for simulating human SCI, but it is difficult to gain its high...