Membrane Resonance And Its Related Research In Rat Subicular Pyramidal Neurons

Frequency preference represents an intrinsic property of neurons. Resonance is described as the ability of neurons to respond selectively to inputs at a preferred frequency. It is essential to characterize the resonance and frequency preference of neurons because they serve as substrates for coordinating network activity in the brain. The subiculum is the pivotal output region of hippocampal formation. It connects the hippocampal formation with many cortical and subcortical regions. The subiculum contributes to the information processing and the theta (θ, 4 - 10 Hz) rhythm output of the hippocampal formation during physiological functions such as memory and learning. In addition, clinical and basic investigations show that changes within the subiculum are related to Alzheimer's disease and temporal lobe epilepsy. Our research include three parts that study the resonant characteristic of subicular pyramidal neurons and its ionic mechanisms, analysis its role in spike timing and synaptic transmission with infrared visual whole-cell patch clamp recording in rat horizontal brain slices.1. The resonant characteristic and its ionic mechanisms of subicular pyramidal neurons.θ oscillation (4-10 Hz) is an important biological rhythm in many brain regions, especially in the hippocampal formation. As one of these intrinsic neuronal properties, θ resonance has been found in hippocampal CA1...