Exploring Studies About Novel Therapeutic Methods Of Malignant Glioblastoma

Malignant glioblastoma is one of the most common malignant tumors in the neurological system. Glioblastoma is an incurable brain tumor that usually causes death within 2 years after conventional therapies consisting of surgery, radiation, and chemotherapy. The therapeutic study on malignant glioblastoma is one of the hotspots of neurosurgery recently. In the present study, we explored two novel methods that might have the potential use in the therapy for malignant glioblastoma. The first study was the inhibited proliferation of human glioblastoma U87MG cells by RNA interference-based knockdown of melanoma antigen gene 1(MAGE-1). The second study was a new chemotherapy based on Asterosaponin 1, a cytostatic compound from the starfish Culcita novaeguineae, functioned by inducing apoptosis in human glioblastoma U87MG cells.MAGE-1 was found by Van der Bruggen in 1991 which was directed the expression of antigen MZ2-E on a human melanoma cell line. It is expressed by the original melanoma cells, melanoma cell lines, and some tumor cells of other histological types. No expression was observed in a panel of normal...