Multiple Serum Autoantibodies Mini-array Analysis On The Subjects With Esophageal And Gastric Cardia Precancerous And Cancerous Lesions

BackgroundEsophageal cancer (EC) is one of the sixth most common malignant tumors worldwide. The remarkable geographical distribution is the striking characteristic for EC. The ratio for EC incidence between the high- and low-risk areas could be as high as 500:1. Moreover, EC has a very poor prognosis. Linzhou City (formerly Linxian County) and its neighboring counties in Henan Province, in northern China have been well known as the highest incidence and mortality area for EC in the world. It has been accepted that human esophageal carcinogenesis is a multistage and progressive process. The early indicator for the subjects predisposed to EC is the abnormal proliferation of epithelial cells, morphologically manifested as basal cell hyperplasia (BCH), dysplasia (DYS) and carcinoma in situ (CIS), which is considered as precancerous lesions of EC nowadays. Another significant feature for EC is its occurring together with gastric-cardiac adenocarcinoma (GCA). The ratio of EC to...