Changes Of Lipid Metabolism In Diabetic Animals And Effects Of Ananas Comosus L. Leaves On Regulation Of Glucose And Lipid Metabolism

Dyslipidemia is common in diabetic patients. However, dyslipidemia in part of diabetic patients is in a potential state. Diabetic patients will produce significant hyperlipidemia if only they have high-fat diets. This phenomenon was shown in alloxan-induced diabetic mice when they were fed high-fat diets. One of main manifestation of diabetic dyslipidemia is postprandial hypertriglyceridemia in diabetic animals, which is correlated with diabetic gastroparesis. Use of natural products, Rheum Palmatum L., may become a new choice to treat postprandial hyperlipidemia in diabetic patients with gastroparesi by improving gastrointestinal transit. High-cholesterol diets (HCD) impair short-term retention of memory in alloxan-induced diabetic mice, but not acquisition of memory nor retention of memory in prediabetic mice, which indicate that controlled HCD may be a strategy to prevent the loss of memory in diabetic individuals after they have acquired new information.The ethanolic extract of Ananas comosus L leaves (AC, 0.4 g/kg) has hypolipidemic effect in the hyperlipidemic models of mice or rats after an acute or long-term treatment, whose mechanisms are involved in the inhibition of lipid absorption and synthesis, and the acceleration of lipid clearance and metabolism. AC also has hypoglycemic effect in the alloxan-induced rats, which is related to inhibit intestinal starch absorption, to accelerate peripheral glucose utility, and to enhance insulin sensitivity. In the cellular experiments, AC and its compounds can inhibit lipid synthesis, accelerate glucose utility and enhance insulin sensitivity. In the experiments in vitro, AC and its compounds can activate lipoprotein lipase activity and inhibit the activities of HMGCoA reductase, hepatic lipase, pancreatic lipase, and amylase. The result of PPARa Western blotting shows that the molecular mechanism of AC is inconsistent with that of fenofibrate. Apart from above, AC and its compounds have additional activities such as anit-oxidation, neuro-proteciton in PC 12 cells exposed to oxygen and glucose deprivation, inhibition of the production of NO in LPS-induced...