Toll-like Receptor 4 Mediated Mechanism Of Bacillus Calmette Guerin And Lipopolysaccharide Inducing Immunological Liver Injury And Role Of Paeoniflorin

Liver injury is pathological basis of various hepatic diseases. A characteristic feature of the pathology is hepatocyte degeneration, necrosis, even apoptosis.Various stimulating factors including biology and chemistry cause activation of hepatical cell, with secreting a large number of cytokines related to inflammation and immune via a series of signal cascade reactions, then leading to hepatocyte injury by complex interaction between different hepatical cells and cytokines. These make hepatic disfunction and develop into hepatic fibrosis. Therefore, it has very important clinical significance to control the development and process of liver injury in time.Innate immunity is the first line of defense of resisting infection of bacterium, fungus and viruses. Recent studies indicate Toll-like receptors are very important receptors to identify pathogens. They play a main role in priming innate immunity and subsequent adaptive immunity. It has been found that Toll-like receptor 4 signal pathway is involved in activating of Kupffer cells, hepatocytes, and hepatic stellate cells, with secreting a large number of cytokine related to inflammatory and immune, which...