A Preliminary Study Of Gene And Protein Markers In Acute Coronary Syndrome Disease

Coronary artery disease(CAD) is the most common cause of death in industrialized countries and is rapidly increasing in prevalence in developing countries.In developing countries,the reduction in childhood mortality is expected to chang demographic structures, with the result that more adults will be at risk from CAD. Morbidity and mortality rates among patients with CAD, remain high in our country. Acute coronary syndrome (ACS) is the most ominous complication of CAD. CAD/ACS has long been know to "run in families". A positive family history of CAD in first degree relatives is a strong independent risk factor for CAD. One approach to preventing this condition is to identify disease susceptibility genes. Throbospondin-l(TSP-l) is syn - thesized and secreted by activated platelets and a variety of cell types , Recently, in the GeneQuest study, researchers have discovered one variation in exon 13 (A8831G) of the TSP-1 gene was significantly associated with a nine fold increased risk for myocardial infarction(MI) in homozygous individuals of 700S allele . In view of these findings we further investigated a possible association of the TSP-1 N700S polymorphism with ACS in a Chinese Han population (the area around Jiangsu and Anhui provinice ) .Cardiac-specific troponin I (cTnI) is well recognized as the morst sensitive and specific marker of myocardial necrosis , regarding to the ACC/ESC,ACC/AHA gurdline on AMI and ACS.Elevation of serum cTnI has been shown to identify patients with ACS at increased risk for adverse clinical outcomes. We now extend our analysis of the patients...