The Expression And Biological Function Of Apoptotic Inhibitory Gene Survivin In Pancreatic Carcinoma

The human pancreatic carcinoma is a common and poor prognostic cancer in gastrointestinal tract. The morbidity of the cancer is gradually increasing over the last years in China. In recent years, the research of pancreatic carcinoma is widely concerned by scientists from most countries in the world. As other malignancies, the development and progression of pancreatic carcinoma is a multistage process that involves a series of genetic alterations. For the last decade, the apoptosis inhibition was found to have important effect on the pathogenesis of pancreatic carcinoma. Survivin is the most recently identified, structurally unique member of the IAP (inhibitor of apoptosis proteins) family. It plays very important role in the development and prognosis of gastrointestinal tract cancers. Survivin is expressed in most human tumors, but rarely expressed in terminally differentiated normal adult tissues, the expression displaying a tumor-specific pattern, which renders it a potential therapeutic target for anti-tumor treatment. In present study, survivin expression, its correlations with clinical pathological characteristics and apoptosis and proliferation levels were detected in human pancreatic carcinoma. Survivin expression in pancreatic carcinoma cell line Pa-Tu8988 was down-regulated using RNA interference. The therapeutic...