Study On Etiopathogenesis Of Idiopathic Portal Hypertension

Background: Idiopathic portal hypertension (IPH) is a disease of unknown etiology. The main clinical manifestations of IPH are splenomegaly, anemia, well-tolerated reoccurring episodes of gastrointestinal bleeding and hepatic parenchymal functions are nearly normal, at the same time, excluding liver cirrhosis, obstruction of extrahepatic portal vein, Budd-Chiari syndrome and congenital liver fibrosis.It is called IPH in Japan, it's counterpart is called non-cirrhotic portal fibrosis(NCPF) in India and hepatoportal sclerosis(HPS)in America. It's etiology and etiopathogenesis remain obscure and may be multifactorial, a number of etiological agents have been postulated, infection, exposure to trace metals and poisonous chemicals, immunologic and immunogenetic abnormalities.These factors affect intimal of intrahepatic portal vein,solely or co-operately.At last, fibrosis of intimal of intrahepatic portal veins and sclerosis and obliteration of small portal vessels occured . But it's concrete pathogenesis is unclear.Purpose: To analysis the clinical manifestations and laboratory data of idiopathic portal hypertension (IPH),and make primary speculations on it's etiology and pathogenisis; To analysis the pathological features of IPH, and try to understand the development of pathologic course and evalue the role of immunity in it's generation and progression. Test of the subgroups of T lymphocyte and total B lymphocytes is performed to elucidate the cell-mediated and humoral immunity status of the body. To determine the role of T helper (h) 1 and Th2 CD4~+ T cells in the pathogenesis of IPH...