Molecular Mechanisms And Effects Of Rosiglitazone On Endothelium-dependent Vasodilation In Type 2 Diabetes

Chapter oneChanges of endothelium-dependent vasodilation and the effects of rosiglitazone on it in patients with IGT and T2DMObjective: To observe the changes of endothelium-dependent flow-mediated dilation (FMD) and to investigate the effects of rosiglitazone(RSG) on it in patients with impaired glucose tolerance (IGT)and type 2 diabetes(T2DM).Methods: One hundred and twenty four patients with IGT and type 2 diabetes were divided into IGT group(36 cases),DMl group(type 2 diabetes without vascular complications,57 cases)and DM2 group (type 2 diabetes with vascular complications,31 cases) ,and 25 normal subjects as normal controls (NC group). The height, weight, blood pressure, fasting plasma glucose(FPG),fasting serum insulin(FINS),glycosylated hemoglobin(FIBA1c),triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) , high density lipoprotein-cholesterol ( HDL-C ) ,serum nitric oxide(NO), tumor necrosis factor-α(TNF-α) and high sensitive C-reactive protein (hs-CRP) were measured in all subjects.The body mass index(BMI),waist circumam-bience/hip circumambience ratio(WHR)and homeostasis model assess-...