The Effects Of Energy Controllable Steep Pulse On The Cell Membrane And Its Safety

The steep pulse which electric field can make the cell death by destroying the cell membrane with irreversible electroporation is a new low and micro trauma method in the treatment of malignant tumor. The safety and the influence of steep pulse on surrounding normal tissue are the prerequisite of it in the treatment. The cell membrane as a biomembrane has very important role in maintaining the stability of cell. The cell membrane potential is one of the most important biophysical characteristics in cell membrane. It has very important function in the cellular normal vital movement, regulating many important cell functions. The changes of cell membrane potential certainly alter the states of ion channel in cellular membrane, which induce the changes of ionic concentration. The changes of ionic concentration may influence the function of intercellular gap junction, which affects the proliferation and activity of tumor cells. So in this succession, we plan to further investigate the influence of ECSP on cellular membrane function and its safety on transplanted tumor rabbit, also give qualitation and quantitation analysis in some key issues concerning the development of ECSP.