Accelerated Renal Progression In The Remnant Kidney Model: Role Of A Diet Rich In Advanced Glycation End Products

BackgroundAdvanced glycation end products (AGEs) accumulate during aging, in diabetes mellitus and actue and chronic renal failure, as well as in liver cirrhosis. Mainly, their accumulation in the kidney and cardiovascular system is assumed to exert toxic effects. To date, the toxicity of parenterally administered AGE-modified proteins has been shown by various animal models, wherease coadministration of substances antagonizing or preventing AGEs actions substantially ameliorated the renal and vascular pathological states.Food-derived AGE-analgues, the Maillard reaction products (MRPs), are formed during their technological heat processing, household heating, and long-term storage. For endogenously formed AGEs, the chemical structure of MRPs is yet poorly defined. In foods, MRPs determine the sensory properties contributing to the formation of textur, aroma, and color of the processed food, giving it its appeal. However, (1) their fate in the organism, (2) potential bioactivity, and (3) contribution to and/or modulating action on the toxicity of endogenously formed AGEs, in particular, in renal insufficiency, largly remain unclear.Studies of rats and healthy humans concurrently have shown that after a signle oral dose, approximately 10% to 30% of ingested MRPs are absorbed into the...