Study On Cardioprotective Effects Of Red Wine

Numerous epidemiological studies have showed that moderate consumption of red wine has much more advantages than that of other alcohol beverages in decreasing the morbidity and mortality of coronary heart disease, which suggests red wine consumed is cardioprotective. As investigated in recent advanced researches, polyphenolic compounds rich in red wine have been conformed to inhibit atherosclerosis by modulating metabolism of plasma lipid and lipoprotein, preventing platelet from aggregation and relaxing cardiovascular smooth muscle. Therefore, study on the beneficial effect of wine and the possible mechanism has been becoming a hot-spot topic.Red wine contains plenty of polyphenolic compounds together with alcohol. On the other hand, alcohol alone consumed with low-to-moderate level in many literatures is beneficial to health, and so does the polyphenolic compounds in wine. However, arguments for the effects from red wine consumption due to alcohol, to polyphenols or to them together still exist. In particular, study on the antioxidant effects from red wine in vitro and in vivo are few, much still less in the research of cardiac vascular dynamics and hemodynamics of red wine, which are important indexes reflecting the function of medicine on the coronary heart disease. Therefore, study on the effects of red wine consumption on human's health and the corresponding mechanisms are of great value. At the same time, the effects of the whole grape seeds rich in polyphenol compounds were also examined.In this study, red wine, de-alcoholized red wine and alcohol were prepared for rats drinking to investigate their individual antioxidant activity in vivo involving the liver antioxidant enzyme and lipid peroxidation. A model of high plasma lipids in golden hamster was established, by which the modulation of high plasma lipids with red wine, de-alcoholized red wine, alcohol and grape seed were measure respectively, and the endothelial material secreted from blood was also analyzed. On the other hand, the effects of red wine, de-alcoholized red wine and alcohol inhibiting platelet aggregation in vitro together with the cardiac vascular dynamics and hemodynamics of them were also examined.The main results obtained were as follows:1. Compared with those of the control group, the consumption of red wine by rats resulted in significant increases in the activities of SOD, CAT and GSH-Px but not the body weight after 12 weeks; the consumption of alcohol increased the activities of CAT and...