Studies On Associations Of The Polymorphisms Of Five Candidate Genes With Male Infertility

ldiopathic male infertility is a kind of disease that is involved in complicated genetic factors. In recent years, there have been intensive studies on the genetic causes underlying male infertility and several genetic etiology were found, such as numeral and structural abnormality of chromosome, microdeletion of azoospermia factor (AZF) on the Y chromosome and mutations of some known genes. However, these genetic defects could account for only about 15% of idiopathic male infertility. Thus, the majority of genes associated with idiopathic male infertility remain to be deciphered.The major form of idiopathic male infertility is spermatogenesis impairment, which was present in 59-90% of all cases. Therefore, the genes related to spermatogenesis are considered as the important candidate for idiopathic male infertility. Human spermatogenesis is a complex process in which a serial of cell function including proliferation , meosis and differentiation are involved. It is eatimated that more than 4000 genes participated in spermatogenesis. With the advancement in gene function, a lot of genes related to spermatogenesis have been identified and characterized in recent years. However, whether all these genes are genetic causes of idiopathic male infertility is still not clear and need to be further studied.Human breast cancer susceptibility gene 2 (BRCA2), recombination...