The Effects Of Site-directed Mutation Of Nm23-H₁ Gene On The Regulating Mechanisms Of Typical Wnt Signaling Pathway In Human High-metastatic Large Cell Lung Cancer Cell Line L9981

Background and objectives: Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the main cause of failure to cure and lose their life of the patients with lung cancer. It is a complex biological behavior that associated with many factors, genes, signal pathways and processes. Therefore, to explore the changes of cell signal transduction related to invasion and metastasis in lung cancer will not only illuminate the molecular mechanism of tumor invasion and metastasis, but also provide a new targeting molecule and route for blocking signal transduction and reversing metastatic phenotype of lung cancer. Our previous researching works have proved that low expression and hetero-deletion of tumor metastasis suppressor gene nm23-H₁ was closely correlated with the high metastasis ability and poor prognosis of patient with lung cancer. nm23-H₁ gene is a key and...