Experimental Study Of ～(32)P Coated Endovascular Stent Inhibiting Neointimal Proliferation In Dogs

In the last 20 years, PTA and PTCA, with their widespread clinical use, have come to be one of the most popular means of interventional therapy in dealing with obstructive vascular diseases. Their therapeutic effectiveness has been greatly threatened by restenosis which occurs in about 1/3 of the patients. It is of great importance to study its mechanisms and means of prevention.Up till now no drugs have been found effective on treating RS which is a response to injury. However there seems a radiotherapeutic way out. From external X-ray beam irradiation to intravascular γ-ray irradiation, from β-particle intravascular irradiation to β-particle emitting stent, every evidence shows that it is a completely new, simple and reliable way of cure. All these reports are from America and Europe but few in China.Purpose:1. to observe the inhibitory effect of ³²P β-particle on aortic smooth muscle cells of New Zealand rabbit.2. to calculate the dose needed to inhabit these cells.3. to work out a home made intravascular stent and discuss the relation between its structure and feature.4. to work out a ³²P coating technique.