| Study purpose:Study through the cultural heritage theories and the clinic collect acute ischemic cerebrovascular disease clinical data and the serum sample, inquiry into begin syndromes of acute ischemic cerebrovascular disease about plain body circumstance with the sufferer, lifeway , food habit, sot, smoke and since go toward the disease history etc. And the angiotensin â… â€”converting enzyme and Angiotenshaogen of the RAS system pivotal Substance gene polymorphism relativity.Study method:1.The theories studyReview the syndromes research and acute ischemic cerebrovascular disease research in recent years, the study physical endowment factor ischemic cerebrovascular disease syndromes to the acute, and the gene set the correlation that learn to wait with physical endowment, syndromes. 2. The clinical studies study:The case comes from Guangdong province Chinese medicine hospital in nerve one section and nerve three sections 2004-2005 years inpatients. According to bring into and expel standard to bring into 118 sufferers, time hospitalized behind according to the outbreak divides for 0-24 hours in, 24-72 hours, 72 hours-7 dayses three time segment for hospitalize a patient to carry oninquisition lately, fill in related "stroke impatient period the syndromes related factor investigate form*. Collect a sufferer the serum sample in the meantime, the adoption PCR method to examine 118 sufferers and 59 health person the ACE I/D gene polymorphism and AGT M/T gene polymorphism. Adopt the SPSS11.0 carries on a data to record to go into, recording to go in to finish to carry on check. Adopt the SPSS11.0 carries on data analysis. Result:l.The physical endowment factor Be the importance of the syndromes to constitute part and can be see to make the physical endowment syndromes, the gene and physical endowment exist an important connection, so can pass the influence physical endowment but the influence syndromes.2. This research manifestati on acute ischemic cerebrovascular disease:The yin syndrome (52. 5%), the yang syndrome( 47. 5%). the yin syndrome is slightly high in the yang syndrome. But the syndrome main factor the occurrence comparison of the fire syndrome, the blood stasis, the breeze syndrome, the phlegm syndrome is higher, respectively is(71. 2%n 59. 3")(k 47.5%, 44.9%). But distributed a circumstance from seven certificate types to see is a medium veins and arteries mostly, but with The breeze- phlegm and blood stasis, hinder venation;0n liver yang upword , breeze fire up disturb;phlegm -hot obstruct fu organs, breeze phlegm up disturb higher, respectively is (42.4%, 28.8%, 22.9%). On the medium Internal fu-organs sick breeze- fire up disturb pure qiao-organs is more. And the Chinese medicine syndrome main factor of the result compare consistently, hinting us to obstruct in the brain of impatient the period regard substantial evidence as principle, falsely the disease is opposite less.3. The impatient period that 118 research manifestati on acute ischemic cerebrovascular disease: In 24 hours the comparison of the breeze is obviously high in 48 hours and in 7 days of sufferer, set comparison, X2=8. 313, P=0. 016. hint extension along with the outbreak time, the breeze syndrome waits to appear a rate to descend. The breeze syndrome and smoke cigarette related, The smoker breeze syndrome occurrence not more the smoker goes up obviously, X=9. 816, P=0. 002. The breeze syndrome sufferer the GCS grade point is slightly low in have no the sufferer of breeze syndrome, set the comparison manifestation t=2.265, P=0. O25.The occurrence comparison of the smoker fire certificate is high in not smoker, set comparison X2=4. 632, P=0. 04. To comparewith male, the comparison of the female debility syndrome is high, set comparison, X!=5.943, P=O. 028. The debility syndrome sufferer the nerve function defection and damage grade point is obviously high sufferer is in the non- debility syndrome Jf=2. 632, P=0. 01. the yin weak and yang strong syndrome sufferer' s nerve function defection and damage grade point is also obviously higher than the non- ying weak and yang strong sufferer, Jf=2. 073, P=0. 04, hint falsely disease nerve function defection and damage severity. The breeze- fire up disturb pure qiao-organs nerve defection and damage function grade point on the no-breeze fire higher, t=2. 633, P=0. 01. The phlegm wet disturb qiao-organs a sufferer the nerve defection and damage function grade point also higher, t=3.415, P=0.001. The phlegm heat inside shut resourcefulness a sufferer the nerve defection and damage function grade point higher, set comparison t=2. 761, P=0. 007. From above analytical can see each type of Internal fu-organs sick nerve function defection and damage in more heavy. On the breeze- fire up disturb pure qiao-organs sufferer the GCS grade point is obviously low in not- this type of sufferer, set comparison t=2. 865, P=0. 028;The phlegm wet disturb qiao-organs GCS grade point obviously low in not- this type of sufferer t=5. 466, P=0. 000. The phlegm heat inside shut the resourcefulness GCS grade point obviously low in not- this type of sufferer, t=3. 867, P=0. 00. yang syndrome the sufferer' s red cell press to accumulate to go up, X2 =4. 771, p=0. 044. The red cell of the fire presses to accumulate to also go up, if =4. 771, p=0. 044. phlegm -hot obstruct fu-organs, breeze- phlegm up disturb the red cell press to accumulate to also go up, X2 =14. 758p=0, 002. hint a hot certificate to exist blood inspissation probably.4. The ACE gene cent type the research manifestation DD type brain obstruct of comparison the more healthy matched control increases obviously, both comparison X 2=6.147, p=0.046. Two sets of gene comparison, X2=4. 052, P=0. 028, D allele gene compares I allele gene brain obstruct of the outbreak go up. The syndrome type research manifestation not the comparison of the II type phlegm syndrome goes up obviously, X 2=4.882, P=0.036;phlegm hot obstruct fu organs, breeze phlegm up disturb type also goes up obviously, X2=9.475, P=0. 002, the comparison that hints D allele gene phlegm syndrome may increase high. Not DD type the comparison of the debility syndrome go up, X2=4. 450, P=0. 036\VaQ. comparison of the debility blood stasis syndrome type also goes up, X2=4. 450, P=0. 036.1he comparison that hints I allele gene debility certificate may bemore , Jf=9. 475, P=0. 002.5. The AGT gene cent type the research manifestation TT type brain obstruct a more healthy matched control of comparison higher, )f=7. 086, p=0. 029.1 allele gene to compare with M allele gene brain obstruct of the occurrence rate go up, both relatively have already shown difference, tf=6. 657, p=0. 012.Not the MM type breeze phlegm and blood stasis, hinder venation, the occurrence rate goes up obviously, Jf=5. 824, P=0. 076;The MT type the liver yang upword , breeze-fire up disturb occurrence rate goes up obviously, Jf=4.138, P=0. 042. Conclusion:l.The acute ischemic cerebrovascular disease to start to regard substantial evidence as principle, the yin syndromes is slightly many and yang syndromes, falsely the disease is opposite less .The pathologic factor regard breeze, fire, phlegm, blood stasis as principle.2. Each syndromes wait the emergence and paroxysm course of illness, disease severity degree, sufferer of the factor since go toward life history, plain body circumstance to have certain relativity, parts of syndromes wait with the body in the meantime inside the change of the environment is relevant.3. the ACE and the AGT gene polymorphism researches hint us: The RAS system pivotal Substance gene polymorphism possibilities and phlegm, blood stasis, weak , fire etc. the syndromes wait main factor existence relativity4. The gene-physical endowment- syndromes exists certain inside contact probably...
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