Study On The Recurrence Or Metastasis Of Hepatocellular Carcinoma And Antiangiogenic Therapy

Hepatocellular carcinoma (HCC) is a common cancer in China and in other Asian countries or south Africa. Although some advance has been achieved for the diagnosis and treatment of HCC, the long term outcome for patients with HCC is still very poor. The prognosis for HCC depends mainly on the clinico-pathological characteristic regarding invasion and metastasis. The major obstacle to the improvement of the prognosis for HCC is the high incidence of recurrence or metastasis (50%-60%) after routine surgical treatment or transcatheter arterial chemoembolization (TACE). Therefore, the present prospective study was designed to investigate the molecules responsible for the invasion potential and postoperative recurrence of HCC by focusing on matrix metalloproteinase (MMP)-9, vascular endothelial growth factor (VEGF) and endostatin. In addition, we also studied the detection of micrometastasis of HCC at a relatively early stage, and the experimental anti-angiogenic therapy for HCC and spontainous murine breast cancer with high metastatic potential.1. Study on the relationship between the expression of MMP-9, VEGF, endostatin and the recurrence or metastasis of HCC...