Effects Of The Spinal Cord Glia In Formalin-induced Visceralgia In Rats

Visceral pain is very common in clinical. It is mainly induced by mechanical drag, changes of ischemia, spasm and inflammation, etc. Viceral pain is a kind of pain that is hard to localize and is always accompanied with referred pain. When the internal organs are injured or inflamed, algesia hypersensitiveness may often occur. There are many hypothesis related with the mechanism of algesia and its-induced referred pain, but the exact one is not clear. We know that different visceralgia has different mechanism. Thus, the mechanism of visceralgia and its therapeutic methods are one of the hot spot of nowadays research. In the past, people thought that the main mechanism of visceralgia and the referred pain accompanied with it is induced by the changes of neuron activity, the functions of glia only provided structural, metabolic and trophic support to central neurons.Today, people think that the changes of central nervous system activity mainly dependent on neurons. Newly researches found that the spinal cord glia (especially astrocyte and microglia) is a critical factor starting and maintaining the neuorpathic pain. Glia is not only the listener of the talk between neurons (message transport), but also is the participant of the communication with neurons. The present many...