Machanisms Of Resistance To Macrolide, Lincosamide, And Streptogramin Antibiotics In Staphylococcus Epidermidis Caused Nosocomial Infection

Staphylococcus epidermidis is the most frequent causes of nosocomial infection and has gained substantial concerntration now. To determine the prevalence of microlide, lincosamide and streptogramin B (MLSb) resistance in S. epidermidis caused nosocomial infection in the multicenter hospital, 126 isolates were collected from inpatients for testing the antibiotic susceptibility to the macrolide erythromycin, the lincosamide clindamycin and the streptogramin quinupristin/dalfopristin. The isolates were mostly resistant to macrolide and lincosamide, but were susceptible to quinupristin/dalfopristin. The resistance phenotypes of erythromycin-resistant isolates were determined by the double-disc test with erythromycin and clindamycin, which showed constitutive phenotype (73.8%), inducible phenotype (10.3%) and MS phenotype in (8.7%). In the cMLSb isolates, the methicillin resistant S. epidermidis (MRSE) proportion appeared high, whereas high methicillin susceptible S. epidermidis (MSSE) proportion was found in the inducible...