The Investigation Of Bone Marrow-derived Hematopoitic Cells Activities From Psoriatic Patients In Vitro

Background:Psoriasis is a common and enigmatic inflammatory skin disease of multifactorial etiology. Many advances have been made regarding the critical role of pathogenic T lymphocytes as triggering the chain reaction of cellular and molecular networks that culminate in the formation of psoriatic lesion. The pivotal role of T cells in psoriasis pathogenesis has been demonstrated by the presence of activated T cells in psoriatic plaques as well as clinical therapy observation using a wide range of immunosuppressive agents or fusion proteins by blocking T cell activation or potentially anergize the pathogenic T cells. Otherwise, lesional and circulating T-cell clones of psoriatic patients have been shown to contribute to the proliferation of keratinocytes via many ways. Further direct evidence in vivo was provided that psoriatic lesion conversion were induced by injecting indermaly psoriatic T cells into skin from normal persons and symptomless skin from psoriatic patients transplanted to severe combined immunodeficient mice (SCID). Varity of exogenous and endogenous factors can activate the immune system with creation of pathogenic T cells. But the inherent dysfunction of psoriatic pathogenic T cells is perhaps more crucial for the pathogenesis. Psoriasis is a complex immunity disorder involving alterations of many cell types. Besides T lymphocytes, many other immunocytes such as B lymphocytes, monocytes, leukocytes, natural killer cells, even red blood cells and blood platelets,...