Single Nucleotide Polymorphismsin Fas And Fas Ligand Genes And Susceptibility To Cervical Cancer

Background and Objective:Human papillomavirus (HPV) plays the causal role in cervical carcinogenesis. However, only a small portion of infected individuals develop cervical cancer. Host genetic factors may confer susceptibility of this disease. Fas and Fas L are important apoptosis genes, abnormal expressions of which exist in many tumors. Single nucleotide polymorphism in the promoter region of Fas (-1377 G/A) and Fas L (-844T/C) genes alter the transcriptional of activity of these genes. This study is to investigate the association between Fas -1377 G/A and Fas L -844T/C polymorphisms and the risk of the development of cervical cancer. Methods:A hospital-based case-control study was conducted, in which 314 cases with primary cervical cancer and 628 healthy controls were frequency matched on age. Blood samples from all subjects were collected, as well as data of demography, smoking history from all...