Acute Aortic Dissection Clinical Analysis And Its Association Study With SNP Of Type â…¡ Matrix Metalloproteinase Gene

BackgroundAortic dissection (AD) is a life-threatening aortic wall disease. At present, manystudies focus on the pathogenesis, diagnostic and therapeutic of AD. Manyinvestigators have studied the clinical data in the IRAD database and provided newinsights into diagnostic and therapeutic implications. To date there is not correlatedreports about gender-related and age-related in large scale AD with regard to clinicalcharacteristics, managements, and outcomes in our country.The matrix metalloproteinases (MMPs) have been widely implicated in thepathogenesis of many cardiovascular diseases. Many studies suggest that AD isrelated to MMP-2 and MMP-9. So we selected gene of MMP-2 and MMP-9 ascandidate gene.Single nucleotide polymorphisms (SNP) of certain genes are diseases related, such ascoronary heart disease and hypertension. Whether SNPs of MMP-2 and MMP-9 genesare related to AD has not been reported. We investigated, therefore, the associationbetween AD with hypertension and the SNPs of MMP-2 and MMP-9 genes.ObjectiveThis article is organized in two parts, with a focus on the gender-related andage-related differences in acute aortic dissection (AAD)in part Ⅰ and emphasis on themolecular biology study in the AAD with hypertension in part Ⅱ. Recent studiesimply that AD may be related to MMP-2 and MMP-9. We investigated the associationbetween AAD with hypertension and the SNPs of MMP-2 and MMP-9 genes.Methods and ResultsIn part I ,we evaluated 161 patients with AAD to assess differences in clinicalfeatures, management, and in-hospital outcomes according to age and gender.28 patients (17.4%) with AAD were <40years of age. Compared with patients ≥40years, younger patients were less likely to have a prior history ofhypertension(P=0.006); however, younger patients were more likely to have Marfansyndrome(P<0.001). Clinical presentations in the two age groups were similar;...