Single Nucleotide Polymorphisms And Therapy Response To Platinum-Based Chemotherapy In Advanced Non-Small Cell Lung Cancer

X-ray repair cross-complementing 1 (XRCC1) plays a key role in DNA base excision repair and cells lacking its activity are hypersensitive to DNA damage. Polymorphisms in the XRCC1 gene may lead to decreased DNA repair capacity and confer inherited predisposition to cancer risk. In this case-control study which included 1024 patients with incident lung cancer and 1118 cancer-free controls matched on age and sex, we genotyped 4 polymorphisms of XRCC1, one in 5'-UTR (T-77C) and three in coding-region (Argl94Trp, Arg280His and Arg399Gln), to determine their associations with risk of lung cancer. We found that compared with -77TT wild-type homozygote, the variant genotypes were associated with significantly increased risk of lung cancer [adjusted odds ratio (OR) = 1.44; 95% confidence interval (CI), 1.18-1.82 for -77TC combined CC genotypes versus TT genotype]. However, no significant associations were observed between other three exonic polymorphisms, Argl94Trp, Arg280His and Arg399Gln, and lung cancer...