Study On The Gene Transcription Pattern In Patients With Myelodysplastic Syndrome

The myelodysplastic syndrome is clonally hematologic disorders characterized clinically and morphologically by ineffective hematopoiesis, they (MDS) have shared features of refractory cytopenia, dysplastic cellular morphology, and a propensity toward malignant transformation. The natural history of these syndromes ranges from a chronic course that may span years to a rapid course of leukemic progression. The variable manifestations and clinical courses are reflected in evolving classification schemes based largely on the morphology of BM cells on aspirate smears and in biopsies. Prognosis is most closely related to the percentages of marrow myeloblasts and also to the presence and character of specific cytogenetic abnormalities. In general, myelodysplastic conditions are preleukemic disorders in which the neoplastic clone is established, but not all cases of myelodysplasia terminate in acute myeloid leukemia (AML).The molecular pathogenesis of MDS remains poorly understood. A proposal for the multistep pathogenesis of MDS is that initial damages can influence the expression of cell-cycle–related genes, including checkpoint and...