Protection Effects Of Vallinin Derivative Dimovanin Against Radiation And Its Mechanism

All the living beings on the earth have been irradiated by ionizing radiation, which might lead to the living beings injury or damage. After ionizing irradiation, radiation can immediately act on the life materials, therfore the life receives the energy that radiatio loses. As a result of radiation energy, there come all kinds of biological effect, such as molecular changes; changes of cell structure, metabolism and function; changes of tissues, organs, systems and their relations.Such injuries include injuring the spinal cords, dysfunction of hematopoiesis, descence of white blood cells and depressing the immunity. Therefore, to study the prevention and cure treatment and the effective drugs on radiation damage is very important and significative. The researchers overseas or at home focus on the studies of the protection of natural drugs on radiation damage, and some traditional Chinese medicine or the main ingredients of them have been researched. In fact, to research the new radioprotector that has few toxin and high curative effect is the new hotspot to study.Vanillin is the extract of vanilla planifolia, which has a very good radioprotection. Vanillin is able to clean out the free radicals to show a good antioxidation. It could inhibit the DNA single strand break, chromosomal break and crosslink by X-rays, and it could also enhance the DNA repair. There, however, high concentration is necessary in vanillin to function the radioprotection. To expect more cure effect, Wang lin, the profesor of academy of military medical sciences, synthesized a series of derivatives of vanillin (P2-P9). Through many experiments, we found that P7 is a prospective candidate for radioprotectors, and P7 was named "dimovanin". So, we paid more attention on dimovanin and explore its mechanism in cellular, molicular and bodily levels.1. Dimovanin and P6 presented no toxin within 50 μM to normal cells by means of cytotoxicity checking and measureing for the vanillin derivatives. Moreover, dimovanin had no proliferous effects on tumor cells after irradiation exposure at 2 Gy y rays, while P6 could expedite the tumor cell proliferation. ESR results also suggested...