Cellular Immune Response In Gastric Lesions Associated With Helicobacter Pylori Infection And Its Correlation With The Occurrence Of Gastric Cancer

Objective:Helicobacter pylori (HP) was firstly cultured from patients endoscopy by Australian scholars Marshall and Warren in 1983, who were awarded Nobel Prize in 2005. HP can produce a lot of urease that can be used to detect the infection. HP is aerobe and colonizes in the epithelium of the human stomach. Studies indicated that the infection was the main cause of gastritis and peptic ulcer and was associated with the occurrence of gastric cancer. Therefore, HP was regarded as one of the first-echelon risk factors that induce gastric adenocarcinoma by WHO. Many researchers discovered that Th1 immune response occurred in patients with acute infection, chronic gastritis, gastric ulcer. Some studies indicated that Th2 immune response predominated in patients with gastric cancer. To explore the changing regularity of Th1/Th2 and the correlation...