Effects And Mechanism Of Pyrrolidine Dithiocarbamate On Lipopolysaccharide-Induced Injuries To Cornea And Human Corneal Fibroblasts

Background Bacterial keratitis is one of the main diseases that can cause permanent loss of vision. It will cause corneal ulceration, perforation, scar formation and even resulting in permanent loss of vision in severe cases. The host response to this infection is critical to the outcome, and is regulated by cytokines produced in the ocular tissue. The upregulation of cytokines and adhesion molecules stimulated by inflammatory mediators and the subsequent infiltration of leukocytes is the main mechanism of corneal inflammation. Investigations show that the expression of many cytokines elevated in pathological progress of bacterial keratitis is interrelated with the degree of injury in cornea. The expression of cytokines is regulated by certain transcriptional factors, among which nuclear transcriptional factor-κ B (NF- κ B) takes part in the transcriptional regulation of many cytokines and inflammation mediator genes regulation. It takes part in many gene' s adjustment, inflammation reaction, immune response and takes part in the cells' proliferation, conversion and apoptosis.NF- κB regulates a host of inflammatory and immune responses by increasing the expression of specific cellular genes, it is the key transcription factor which controls many proinflammatory genes expression. Therefore, NF-κ B...