Application Study Of 3T MR Functional Imaging In Patient With Musculoskeletal Tumors

ObjectiveTo study benign and malignant musculoskeletal tumors with magnetic resonancedynamic contrast-enhanced (MR-DCE) imaging, MR diffusion-weighted imaging(MR-DWI), ³¹P MR spectroscopy (³¹P-MRS) and ¹H MR spectroscopy (¹H-MRS) at 3 Tesla MR scanners and to assess the usefulness of MR-DCE, ³¹P-MRS, !H-MRS and MR-DWI in diagnosing musculoskeletal tumors and distinguishing benign from malignant musculoskeletal tumors.Materials and MethodsThirty five patients with musculoskeletal tumors proved clinically and pathologically were examined with MR-DCE, MR-DWI and ³¹P-MRS. Eight patients were examined with ¹H-MRS additionally. 1, Using the 3D fast spoiled gradient echo (FSPGE) sequence the entire lesion underwent multi-slice MR-DCE. The MR signal intensity of ROI was shown in the time-signal intenisty curve(TIC), and the dynamic contrast-enhanced parameters-maximum slope of increase(MSI), maximum slope of decrease(MSD), positive enhancement integral (PEI),signal enhancement ratio(SER) and time to peak (T_peak) were ananlysed statistically. 2.³¹P-MRS was performed with phosphorus surface coil. The areas under the peaks of various metabolites in spectra were measured. The ratios of the other metabolites to β -ATP,NTP and Pcr were calculated. Intercellular pH was calculated according to the chemical shift change of Pi relative to Pcr. ¹H-MRS was performed to study malignant musculoskeletal tumor(n=5), benign ones(n=3), and normal muscules adjacent to lesions.