Protective Effects Of JiaWeiBuGan Decoction On Diabetic Peripheral Neuropathy In Diabetic Rats And Its Mechanism

Background and Objective: Diabetic peripheral neuropathy(DPN) is one of the major factors of chronic complication and mutilation caused by diabetes mellitus. Finding effective medicines for diabetes mellitus is a focus of modern researches. Although there has been great progress in the study of molecule mechanism about polyol pathway, advanced glycation end products,protein kinase C and hexosamie .Clinically effective diabetic peripheral neuropathy treatments remain elusive and ultimately. Strategies must look beyond the single pathway for a more integrative answer to diabetic peripheral neuropathy. The theory of unifying mechanism was proposed by Browlee et al . In 2001 ,in which it said that the four hypothesis forementioned probably based on the consequences following excessive oxygen free radicals produced in the mitochondrial electron transport chain under the conduction of high glucose. It was all outstanding superiority that this theory had considered the damages to peripheral nerves caused by oxygen free radicals as an integrity process via various channels in researches in DPN, instead of single channels. At the same time, it is interesting that attaching importances on regulation in integrity is a protrudent feature of Traditional Chinese Medicine(TCM) in therapy. And according to many years of clinical observation in JiaWeiBuGan(JWBG)decotion, it really has obvious therapeutic effects on DPN. It is also proved anti-oxidative stress in previous laboratory researches. The objectives of the research ,by using the diabetic models induced by streptozotocin, are to observe the changes of oxidation and anti-oxidative defense system of organism and peripheral nerve in experimental diabetes rats, and to study the relation between these changes and NGF ,Caspase-3 expression and apoptosis in Schwann cell and dorsal root ganglion neuron. In this study,we hope to investigate the possible mechanism of Protective effects of Jiaweibugan Decoction on diabetic peripheral neuropathy in diabetic rats and provide JWBG Decoction with evidence of theory in therapeutic effects.