Study On Transcriptional Regulation And Tumorigenicity Of Embryonic Stem Cell Factor Foxd3

Embryonic stem(ES)cells are pluripotent cells derived from inner cell mass ( ICM) of fertilized eggs. ES cells can not only undergo unlimited self renewal but also differentiate into virtually all types of cells, a fundamental property critical for regenerative medicine. Pluripotency maintenance of ES cells is a precondition for usage of ES cells in regenerative medicine, which will provide enough ES cells source. Current knowledge has elucidated that the self-renewal and pluripotency maintenance of ES cells require a lot of players. Nanog and Foxd3 are two members of them.Foxd3 is a member of winged helix/forkhead family of transcriptional regulators. It is mainly expresses in embryonic stem cells and their malignant equivalent. During early embryo development, Foxd3 mRNA has been detected in blastocyst-stage embryos and throughout the epiblast of the 6.5 days postcoitum (dpc) embryo. It has the capacity of pluripotency maintenance of ES cells. Xu and his colleagues overexpressed Foxd3 in 32D myeloid cells, and found that 32D myeloid cells failed to differentiation when stimulated with G-CSF but continued to proliferate...