Adenovirus-Mediated Ribosome Protein Gene RPS26 Transfer In Influence The Growth And Differentiation Of Human Extranodular Nasal Type NK/T Cell Lymphoma

Nasal type NK/T cell lymphoma is a primary extranodal lymphoma with special morphology, immunophenotype and biological behavior, and which is highly associated with Epstein-Barr Virus (EBV) infection. The tumor cells are usually express of both T-cell differentiation antigens and NK cell associated antigens. So far, it has been acknowledged that T-cell and NK cell share the same progenitor, which differentiates to T-cell or NK cell under different condition. Because the tumor original from the early stage of the progenitor's differentiation, nasal type NK/T cell lymphoma is used to identify the tumor now. It has been listed as an entity of lymphoma in the World Health Organization Classification for Tumors of Haematopoitic and Lymphoid Tissues published in 2001. Nasal type NK/T cell lymphoma occupies a relatively higher incidence in Asia and South America regions than that of in Europe and North America, so that it is a special entity in Asia and also in China. About 60 cases of the tumor are newly diagnosed each year; it occupies about 13.83% of all lymphoma cases and 15.85% of all non-Hodgkin lymphoma cases in the Department of pathology West China...