An Experimental Study Of Closed Traumatic Brain Injury By A New Animal Model In Rat

BackgroundTraumatic brain injury (TBI), which can result in death, disablity and long-term changes in quality of life, is clearly a major injuries threatened to the life of people in the world. An estimation about 2 million head injuries occur every year in the United States. The cost to society is more than $300 billion annually. Trauma brain injury is the leading cause of death and disability in the United States for individuals younger than 45 years and the third leading cause of death in the general population. The recent National Institutes of Health (NIH) Consensus Development Panel on Rehabilitation of Persons with Traumatic Brain Injury noted that traumatic brain injury is of major public health concern.There are no authoritative statistical reports on this aepect in China. However, because of large population, the continuous development of transportation or construction, the incidence of TBI is increasing yearly. Traumatic brain injury has become the major cause of threatening people's life.For a long time, lots of scholars are widely concerned about the research of TBI. They have studied extensively the cause, biomechanical mechanism, biopathology, pathomorphology and molecular pathology of TBI from different aspects. Among which, establishing animal models of TBI become the main objective of the study.An ideal model of TBI, which can not only reflects the characteristics of human injury but also easy to observe the changes of injury and deal with impact factors, is one of the main goal of our long-term study. We can simulate the occurrence of TBI, and study...