The Studying For Genesis And Development As Well As Regeneration Of Pancreatic Islet In Related Genes

ObjectiveTo clarify the differentiation and migration of islet cells as well as islet forming in pancreatic genesis and development, and the expressing changes of related genes in pancreatic development. Meanwhile, Initial investigation were established for mechanism of islets regeneration after β-cells injured. Part vital genes related to islet cells differentiation and development of embryo such as Pdx-1, Ngn3, Nkx2.2 and Nkx6.1 were detected in islets regeneration. It expected to provide elementary investigation for the biological application to finally cure diabetes mellitus. Material & MethodsSample collection was conducted in accordance to the principle of informed consent. Histological method and immunohistological methods were adopted in studying normal embryonic pancreas of donators at 3-14 weeks of gestation, and analysis were made on vital cytokines expression of CD34, AFP, IGF-I, IGF-IR, TGF-β, TGF-βR, bFGF and FGFR for...