| Vincristine (VCR) is a dimer-indo-alkaloid which was extracted from the leaves of Gatharanthus roseus in 1962. With the ability of interfering with the metabolism of tumor cell by binding to tublin, VCR is mainly used to treat acute lymphocytic cell leukemia, Hodgkin and non- Hodgkin lymphama in clinic, and it is also useful in the treatment of breast cancer, bronchiogenic cancer, soft-tissue sarcoma, neuroblastoma and so on. VCR is rapidly widely distributed after i.v. administration and reach high concentration in nerve and muscle, so its main adverse effect is neurotoxicity. with continuous intravenous infusion, Toxicity caused by high drug concentration can be avoided and the time of drug with effective concentration stay in blood is also be extended. But patients have bad compliance in this treatment. Transdermal Drug Delivery System (TDDS) has peculiar advantageous exceeding other drug administration, such as avoiding the first-pass effect of liver and the gastrointestinal effects, controlling drug releasing with pharmaceutical technique, avoiding peak and through concentration utilizing skin as drug storehouse, curing the inside diseases through the outside treatment with low toxicity, so it is honored as intravenous drip without needle. As all know, drugs with molecular weight exceeding 5000 show a strong tendency to transport to lymph in dermis. So, with a proper transdermal carrier, VCR can penetrate the skin and be targeted delivered to lymph. Consequently, TDDS and TDS are combined together, which can strengthen the efficiency of VCR and relieve its side effect. And this academic thought has not been reportedWith a dry-film and ultrasonic dispersing methods, vincristine loaded transfersomes (VCR-T) was prepared with soybean phospholipid (SP) and... |
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