Study Of The Excretion Level Of Corticotropin-Releasing Hormone In Intrahepatic Cholestatic Placental Tissue

[Objectives] Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy-related disease emerging during the second half of pregnancy and does great harm to the fetus. It is associated with a high rate of premature delivery, meconium stained amniotic fluid, antepartum fetal death, and fetal anoxia and stillbirth. To date, the etiology and pathogenes of it is unclear. Recent studies have revealed that the acute hypoxia stress of human utero-placental-fetal units related with fetal unwell outcome in obstetric cholestasis . Corticotropin releasing hormone(CRH), a 41-amino acid peptide hormone produced by hypothalamic neurons, is among the major stress-related neuropeptides and with an important complex neuroendocrine and behavioral adaptation. The human placenta and other gestational intrauterine tissues at term produce and secrete large quantities of corticotropin releasing hormone.CRH derived from the human placenta that represents the...